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KMID : 0380420030270020077
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Journal of Prventive Veterinary Medicine
2003 Volume.27 No. 2 p.77 ~ p.82
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The Therapeutic Effect of Antimicrobial Peptide(Buforin Ⅱb) against Piglet Diarrhea in the Field Test
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Abstract
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The objectives in the present study were to evaluate the therapeutic effect of antimicrobial peptide (Buforin Ⅱ b) against piglet diarrhea in the field test. Experiment was conducted to evaluate the efficacy of Buforin Ⅱb on piglets having diarrhea with two treatments; Treatment A (2 mg of Buforin Ⅱ b/ml) and Treatment B (4 mg of Buforin Ⅱb/ml). Changes in body weight, average daily gains, diarrhea index and shedding of hemolytic E. coli were monitored for the experimental period under field conditions. In this study ( n= 40 pigs), Treatment A and B group reduced diarrhea index(p<0.01, p<0.001) and shedding of hemolytic E. coli, and increased body weight and average daily gain, compared to the Control(+) group. This study indicated that Buforin Ⅱb had therapeutic effect and possibility for treatment in piglets having diarrhea.
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